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槲皮素和17-AAG对大鼠外周血淋巴细胞辐射敏感性的影响研究

褚薛刚 洪承皎 张保国

辐射防护2012,Vol.32Issue(1):28-33,6.
辐射防护2012,Vol.32Issue(1):28-33,6.

槲皮素和17-AAG对大鼠外周血淋巴细胞辐射敏感性的影响研究

Effect of Quercetin and 17-AAG on Radiosensitivity of Rat Peripheral Blood Lymphocyte

褚薛刚 1洪承皎 1张保国1

作者信息

  • 1. 苏州大学医学部放射医学与公共卫生学院,江苏省放射医学与防护重点实验室,江苏苏州215123
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摘要

Abstract

To investigate the effect of quercetin and 17-AAG on proliferation and on radiosensitivity of blood lymphocyte cells.CCK-8 assay is performed to evaluate the cytotoxicity of Quercetin on proliferation of blood lymphocyte cells.CCK-8 assay employed to observe its effects on the radiosensitivity of the cells quantified by calculating the sensitive enhancement ratio(SER).CCK-8 results showed that the inhibition of Quercetin on the cells was the dose-dependent and time-dependent,and the results of assay showed the inhibition of 17-AAG on blood lymphocyte cells was the dose-dependent and timedependent.The study showed that Quercetin and 17-AAG have no effect on the radiosensitivity of the blood lymphocyte cells.

关键词

槲皮素/17-AAG/大鼠外周血淋巴细胞/辐射敏感性/细胞增殖

Key words

quercetin/17-AAG/radiosensitivity/proliferation/blood lymphocyte cells

分类

医药卫生

引用本文复制引用

褚薛刚,洪承皎,张保国..槲皮素和17-AAG对大鼠外周血淋巴细胞辐射敏感性的影响研究[J].辐射防护,2012,32(1):28-33,6.

基金项目

国家自然科学基金资助项目 ()

辐射防护

OA北大核心CSCDCSTPCD

1000-8187

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