辐射防护2012，Vol.32Issue(1)：48-52,5.
低聚壳聚糖与银杏叶聚戊烯醇配伍对辐射损伤小鼠微核率及p53、Gadd45蛋白表达的影响
Study of Compatibility of Oligo-chitosan and Ginkgo Bilobal Polyprenol Influences on Micronuclear Rates and p53,Gadd45 Protein Expression of Radiated Mice
摘要
Abstract
Study of compatibility of oligo-chitosan and ginkgo bilobal polyprenol（GP） influences on micronuclear rate and p53,gadd45 protein expression of radiated mice.Survival rate and survival time of 30-day-time of radiated mice was studied with the mixture of compatibility of oligo-chitosan and different density of GP.High survival rate of mixture density was screening.Another study on this mixture density was about micronuclear rates of marrow and p53,gadd45 protein of spleen after mice were radiated 12 h.The mixture of 300 mg/kg oligo-chitosan and 5 mg/kg GP could increase remarkably the survival rate and survival time of 30-day-time of radiated mice and degrade micronuclear rates and p53,gadd45 protein expression.Compatibility of oligo-chitosan and GP could effectively raise the survival rate of radiated mice.It could proved initially that the mixture has the function of radiation protection.关键词
低聚壳聚糖/银杏叶聚戊烯醇/配伍/辐射损伤/微核率/p53蛋白/Gadd45蛋白Key words
oligo-chitosan/ginkgo bilobal polyprenol/compatibility/radiation damage/micronuclear rates/p53 protein/gadd45 protein分类
医药卫生引用本文复制引用
郭剑平,刘春卉,王永利,魏锦萍,杨仲田..低聚壳聚糖与银杏叶聚戊烯醇配伍对辐射损伤小鼠微核率及p53、Gadd45蛋白表达的影响[J].辐射防护,2012,32(1):48-52,5.基金项目
国家“十一五”基础科研项目 （）
