法医学杂志2012，Vol.28Issue(1)：18-20,3.DOI:10.3969/j.issn.1004-5619.2012.01.004
急性心肌缺血猝死心肌中FAPα和TGF-β1的表达
Expression of FAPα and TGF-β1 in Sudden Deaths due to Acute Myocardial Ischemia
摘要
Abstract
Objective To explore the expression of fibroblast activation protein a (FAPα) and transforming growth factor-β1 (TGF-β1) in myocardial cytoplasm for the cases of sudden death due to acute myocar-dial ischemia. Methods The heart tissues of 47 cases were collected. All cases were divided into three groups: control group, acute myocardial infarction group and recurrent myocardial infarction group. FAPa and TGF-β1 expressions were explored in myocardial cytoplasm by immunohistochemistry technology. The staining results were collected by image analysis system and then the positive area ratio and average optical density were detected. The positive signal differences were compared among the groups. Results Strong FAPa and TGF-β1 expressions were detected in myocardial cytoplasm in both acute and recurrent myocardial infarction groups. The expression of FAPa was not detected in myocardial cytoplasm in control group and TGF-β1 expression showed a weak positive result. FAPa and TGF-β1 expressions showed the statistical difference (P<0.05) in myocardial infarction (acute and recurrent) groups and control group. Conclusion FAPa and TGF-β1 can be the diagnostic markers for determing acute myocardial infarction.关键词
法医病理学/免疫组织化学/心肌缺血/转化生长因子β1/成纤维细胞激活蛋白αKey words
forensic pathology/ immunohistochemistry/ myocardial ischemia/ transforming growth factor -β1/ fibroblast activation protein a分类
社会科学引用本文复制引用
袁翔天,彭雪,靳占峰..急性心肌缺血猝死心肌中FAPα和TGF-β1的表达[J].法医学杂志,2012,28(1):18-20,3.基金项目
黑龙江省政府博士后科研启动基金(LRB07-144) （LRB07-144）
