高等学校化学学报2011，Vol.32Issue(12)：2800-2805,6.
4-(7-甲氧基-2,2-二甲基-2,3-二氢苯并呋喃-5-基)-2-芳氨基噻唑的合成、晶体结构及杀虫活性
Synthesis, Crystal Structure and Insecticidal Activity of 4- ( 7-Methoxy-2,2 -dimethyl-2,3 -dihydrobenzofuran-5 -yl ) -N- ( aryl ) thiazol-2-amine
摘要
Abstract
In order to find novel insecticides with high activity, a series of 4-(7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran-5-yl)-N-( aryl ) thiazol-2-amines was synthesized from 2-(2-methylallyloxy)phenol with Claisen rearrangement, cyclization of furan, etherification, Friedel-Crafts acylation, a-bromation and cycliza-tion of thiazole. Their structures were confirmed by mass spectrometry(MS) , H NMR spectra and elemental analysis. The crystal structure of compound 7j was determined by X-ray diffraction analysis. The crystal belongs to the monoclinic system, space group C2/c with a= 2. 21140(12) nm, 6 = 0.87602(5) nm, c = 2. 13911(12) nm, β = 115. 5380(10)°; V=3. 7391(4) nm3, 7=8, Dc = 1.375 g/cm3, F(000) = 1616, S=1.046, β, = 0.333 mm-1, the finalR1 =0.0390 and Wr2=0. 1079. The preliminary bioassays indicated that compound 7a, 7b, 7h and 7t exhibited insecticidal activity against Aphis fabae were 95. 12% , 62. 60% , 57. 53% and 59. 06% , respectively, at 500 mg/L.关键词
4-(7-甲氧基-2,2-二甲基-2,3-二氢苯并呋喃-5-基)-2-芳氨基噻唑/杀虫活性/晶体结构Key words
4-(7-Methoxy-2,2-dimethyl-2,3-dihydrobenzofuran-5-yl) -N-( aryl) thiazol-2-amine/ Insecticidal activity/ Crystal structure分类
化学化工引用本文复制引用
罗先福,胡艾希,王宇,叶姣,王晓光,欧晓明..4-(7-甲氧基-2,2-二甲基-2,3-二氢苯并呋喃-5-基)-2-芳氨基噻唑的合成、晶体结构及杀虫活性[J].高等学校化学学报,2011,32(12):2800-2805,6.基金项目
国家科技支撵计划项目(批准号:2011BAE06801)资助. （批准号:2011BAE06801）
