高等学校化学学报2011，Vol.32Issue(12)：2806-2811,6.
1-(4-取代苯基)-4-苯基-5-(2-羟基苄基)氨基-1,2,3-三唑类衍生物的合成及抑菌活性
Synthesis and Antibacterial Activities of 1-(4-Substituted phenyl)-4-phenyl-5- ( 2-hydroxy benzyl ) amino-1, 2,3-triazole Derivatives
摘要
Abstract
In order to search for novel and high active fungicides with triazole moiety, a series of novel l-(4-substituted phenyl)-4-phenyl-5-substituted-l ,2,3-triazole derivatives was designed and synthesized by means of combining segments o-hydroxy phenyl and 1,2,3-triazole. Firstly, l-(4-substitutedphenyl)-4-phenyl-5-(2-iminomethyl phenol)-1,2,3-triazole derivatives(3a-3e) were designed and synthesized through diazotization, azidozation, ring-closure reaction and condensation, and then were reduced by sodium borohydride to synthesize l-(4-substituted phenyl)-4-phenyl-5-(2-hydroxy benzyl) amino-1,2,3-triazole(4a-4e). The structures of final products were determined by ' H NMR, elemental analysis and IR. The results of antibacterial activity showed that the title compounds except 3e and 4e had over 95% inhibitory rate against Monilia albican, and over 85% inhibitory rate against Escherkhia coliis at a mass concentration of 0. 1 mg/L. The results suggest that the title compounds might be potential candidates for antibacterial drugs.关键词
1-(4-取代苯基)-4-苯基-5-水杨醛亚胺-1,2,3-三唑/1-(4-取代苯基)-4-苯基-5-(2-羟基苄基)氨基-1,2,3-三唑/抗菌药物/抑菌活性Key words
1-(4-Substituted phenyl)-4-phenyl-5-(2-iminomethyl phenol)-l ,2,3-triazole/ l-(4-Substituted phenyl)-4-phenyl-5-(2-hydroxybenzyl)amino-1,2,3-triazole/ Antibacterial drug/ Antibacterial activity分类
化学化工引用本文复制引用
赵芡,卢俊瑞,辛春伟,鲍秀荣,高海燕,赵旭,李莎,芮甜甜..1-(4-取代苯基)-4-苯基-5-(2-羟基苄基)氨基-1,2,3-三唑类衍生物的合成及抑菌活性[J].高等学校化学学报,2011,32(12):2806-2811,6.基金项目
国家自然科学基金(批准号:20776114,20976135)和天津市高校科技发展基金(批准号:2006ZD33)资助. （批准号:20776114,20976135）
