高等学校化学学报2012，Vol.33Issue(1)：90-95,6.DOI:10.3969/j.issn.0251-0790.2012.01.015
基于多巴胺自聚合及肝素固定改善钛的血液相容性
Blood Compatibility Improvement of Titanium via Self-polymerization of Dopamine and Covalent Graft of Heparin
摘要
Abstract
Self-polymerization of dopamine and immobilization of heparin were applied for surface-modification of titanium in order to improve its blood compatibility. Surface modification was developed via self-polymerization of dopamine and covalent graft of heparin. Surface elemental composition was analyzed qualitatively by X-ray photoelectron spectroscopy ( XPS ). Surface heparin content was detected by toluidine blue 0 ( TBO ). Surface hydrophilicity and hydrophobicity were characterized by water contact angle measurement. Hemolysis rate test, which was applied for detection ofhemolytic ability, was combined with activated partial thromboplas-tin time test(APTT) and platelet adhesion test to evaluate blood compatibility. The results showed that self-polymerization of dopamine was achieved on titanium surface. Heparin was successfully immobilized onto polydopamine layer by covalent graft. The heparin-modified surface could result in a significantly improved hydrophilicity, low hemolysis rate, prolonged APTT and a remarkablely decrease both in adhesion amount and activation degree of platelet. The blood compatibility of titanium could be significantly improved by the method of self-polymerization of dopamine and covalent graft of heparin. This study provides potential application for cardiovascular implants materials with anticoagulant properties.关键词
钛/多巴胺/肝素/血液相容性Key words
Titanium/ Dopamine/ Heparin/ Blood compatibility分类
化学化工引用本文复制引用
谢槟,李贵才,代璐,杨苹,黄楠..基于多巴胺自聚合及肝素固定改善钛的血液相容性[J].高等学校化学学报,2012,33(1):90-95,6.基金项目
中央高校基本科研业务费专项资金(批准号:2010XS32)、国家"九七三"计划项目(批准号:2005CB623904)和国家自然科学基金(批准号:30870629)资助. （批准号:2010XS32）
