高等学校化学学报2012，Vol.33Issue(2)：426-429,4.DOI:10.3969/j.issn.0251-0790.2012.02.038
一种新型磁共振成像造影剂的制备及性能
Synthesis and Properties of a Novel Contrast Agent
摘要
Abstract
Chitosan oligosaccharides (CSn, n = 6, 8, 11) with narrow molecular weight distribution and low polymerization degree were introduced into diethylenetriamine pentaacetic ( DTPA) by acylation reaction. The synthesized novel ligands were coordinated to Mn2+, then the paramagnetic Mn2+-based complexes were gained. The structures of synthesized ligands and the corresponding complexes were characterized by IR, elemental analysis, and ICP-AES. The longitudinal relaxivities(r1) were measured. The results show that r, of Mn-DTPA-CSn are higher than that of commercial contrast agent Gd-DTPA. Besides, the thermodynamical parameters of the interaction between the functional complexes and bovine serum albumin ( BSA) were conducted by isothermal titration calorimetry(ITC).关键词
造影剂/壳聚糖/弛豫率/等温滴定微量热(ITC)Key words
Contrast agent/ Chitosan/ Relaxivity/ Isothemal titration calorimetry(ITC)分类
化学化工引用本文复制引用
杨晓露,杨兴旺,黄燕,张岐,吴静波,曹本男,张小燕..一种新型磁共振成像造影剂的制备及性能[J].高等学校化学学报,2012,33(2):426-429,4.基金项目
国家自然科学基金(批准号:20871061)、江苏省科技支撑计划(批准号:SBE201077304)、海南大学奖励基金(批准号:hd09xm07/24)、海南省自然科学基金(批准号:209001)和江苏大学学生科研立项(批准号:09A053)资助. （批准号:20871061）
