广东医学2012，Vol.33Issue(5)：587-590,4.
加巴喷丁对长春新碱致神经病理性疼痛小鼠大脑皮层脑啡肽的影响
The effects of gabapentin on cortical enkephalin in mice with vincristine-induced neuropathic pain
摘要
Abstract
Objective To evaluate the role of cortical enkephalin in vincristine - induced neuropathic pain in mice, thus to assure the mechanism of gabapentin in prevention of neuropathic pain. Methods The cortical enkephalin expression in vincristine - induced pain group ( Group V ), gabapentin treatment group ( Group C ), gabapentin control ( Group G ) and saline control group ( Group N ) were assessed with RT - PCR and ELISA. Meanwhile, the thermal pain threshold and morphologic observation of sciatic nerve under light and electron microscopy were also recorded. Results An irregular shaped cross - section with thickened, loose texture and stainless myelin, scattered with necrosis lesions was observed in Group V. No significant difference in enkephalin expression was revealed between Group V and Group N or Group C. Conclusion The primary axonal degeneration and secondary demyelination are involved in vincristine - induced neuropathic pain, with no correlation with cortical enkephalin, which is not involved in the gabapentin prevention of vincristine - induced neuropathic pain.关键词
长春新碱/神经病理性疼痛/加巴喷丁/脑啡肽Key words
vincristine/neuropathic pain/gabapentin/enkephalin引用本文复制引用
皮倩,梁锐,潘灵辉,钱卫,林飞,李昌龙,刘悦..加巴喷丁对长春新碱致神经病理性疼痛小鼠大脑皮层脑啡肽的影响[J].广东医学,2012,33(5):587-590,4.基金项目
广西自然科学基金资助项目(编号:2011GXNSFA018193) （编号:2011GXNSFA018193）
