广东医学2012，Vol.33Issue(5)：608-611,4.
风湿性心脏病二尖瓣狭窄心房颤动与窦性心律心肌细胞起搏电流密度的差异
The difference in the funny current densities between atrial fibrillation and sinus rhythm in human atiral myocaridocytes from patients with rheumatic mitral stenosis
摘要
Abstract
Objective To analyze the difference in the funny current ( If ) densities between the atrial fibrillation ( AF ) and sinus rhythm ( SR ) in human atiral mycaridoocytes from patients with rheumatic mitral stenosis. Methods By acute separation method, the human atrial myocaridocytes were divided into Group AF and Group SR. The If densities were recorded for comparison. Results With the test potential between -40 mV and - 140 mV, there were significant differences in the funny current densities between the Group SR and Group AF ( P ＜0. 01 ). And the difference reached peak [ ( -42. 98 ±2. 77 ) vs ( - 26. 93 ± 1. 08 ) pA/pF ] with the test potential of - 70 mV. Conclusion The funny current density in AF in human atiral myocaridocytes is larger than that in SR, suggesting that the increase of funny current density may lead to AF, thus contributes to the pathogenesis of AF in rheumatic mitral stenosis.关键词
风湿性心脏病二尖瓣狭窄/心房颤动/窦性心律/起搏电流Key words
mitral stenosis of rheumatic heart disease/atrial fibrillation/sinus rhythm/funny current引用本文复制引用
钱俊,周华富,赵超仁,徐先增..风湿性心脏病二尖瓣狭窄心房颤动与窦性心律心肌细胞起搏电流密度的差异[J].广东医学,2012,33(5):608-611,4.基金项目
广西科学研究与技术开发计划项目(编号:桂科攻0816004-24) （编号:桂科攻0816004-24）
