国际医药卫生导报2012，Vol.18Issue(2)：163-165,3.DOI:10.3760/cma.j.issn.1007-1245.2012.02.006
胆肠内引流术后早期肠内、肠外营养对大鼠肠免疫屏障功能及内毒素的影响
Effects of early enteral and parenteral nutrition after biliary enterostomy on the intestinal immune barrier and endotoxin of rats
李梅生 1彭翔 1陈焕伟 1周永辉 1蒋鹏1
作者信息
摘要
Abstract
Objective To compare the effects of early enteral nutrition(EN)and parenteral nutrition(PN)after biliary enterostomy on the intestinal immune barrier and endotoxin by establishing a simple animal model.Methods 30 male Wistar rats were randomly divided into 3 groups,the control,EN and PN groups,10 rats for each group,and different nutritional routes employed.7 days after animal model establishment,2 cm ileum in length 3 cm away from cecum were resected,CD4+,CD8+ T lymphocytes were detected by flow cytometry technique,portal vein blood was taken simultaneously to detect endotoxin.Resulst Comparing with control and PN groups,the percentage of CD4+T lymphocytes and CD4/CD8 of EN group were higher(P＜ 0.05); its portal vein endotoxin level significantly lower than that of the formers.Conclusion Early EN after biliary enterostomy for obstructive jaundice has protective effects on intestinal immune defense.It is helpful to decrease postoperative intestinal derived infection.关键词
梗阻性黄疸/肠内营养/肠黏膜免疫/大鼠Key words
Obstructive jaundice/Enteralnutrition/Intestinal mucosalimmune/Rats引用本文复制引用
李梅生,彭翔,陈焕伟,周永辉,蒋鹏..胆肠内引流术后早期肠内、肠外营养对大鼠肠免疫屏障功能及内毒素的影响[J].国际医药卫生导报,2012,18(2):163-165,3.
