广东药学院学报2011，Vol.27Issue(6)：555-558,4.DOI:10.3969/j.issn.1006-8783.2011.06.001
葛根素分散片的处方筛选及其溶出度测定
Study on preparation and dissolution of dispersible tablets of puerarin
周臻1
作者信息
- 1. 广东药学院 医药化工学院,广东 广州 510006
- 折叠
摘要
Abstract
Objective To optimize the preparation process of dispersible tablets of puerarin and evaluate its dissolution rate in vitro. Methods Orthogonal experiment was performed with disintegration time as index, in which microcrystalline cellulose ( MCC) + L-hydroxypropylcelulose ( L-HPC), polyvinylpyrrolidone (PVPP )and magnesium stearate were investigated for the optimal formula. The dissolution rate of dispersible tablets in vitro was determined by UV-spectrophotometry. Results The optimal formula was as follows; MCC + L-HPC 20% , PVPP 1.5% , magnesium stearate 0. 8%. The dispersible tablets disintegrated in 25 s,and the dispersible uniform was excellent. The drug was completely released within 30 min. Conclusion The dispersible tablets of puerarin have a fast, homogeneously dispersing profile and good releasing characteristics, which is suitable for clinical needs.关键词
葛根素/分散片/正交试验/溶出度Key words
puerarin/ dispersible tablet/ orthogonal experiment/ dissolution rate分类
药学引用本文复制引用
周臻..葛根素分散片的处方筛选及其溶出度测定[J].广东药学院学报,2011,27(6):555-558,4.
