人乳头瘤病毒预防性疫苗及其策略展望OACSTPCD
Prospectives for Human Papillomavirus,Prophylactic Vaccine and Vaccination Policy
宫颈癌是中国女性最常见的肿瘤之一.人乳头瘤病毒(HPV)感染是宫颈癌及其癌前病变的必要因子.HPV的病毒样颗粒(由HPV病毒基因组L1基因编码)可产生中和抗体,其结果是HPV病毒样颗粒的注射可有效地预防某个HPV型别的感染.由于HPV16和18两个型别在宫颈癌中具有较高的流行率,这两个型别的病毒样颗粒已被开发成为预防性疫苗.近年来,由两家主要的疫苗厂商生产的两种HPV预防性疫苗的临床结果表明,HPV预防性疫苗是安全的.同时,对于预防低等级的宫颈上…查看全部>>
Cervical cancer is a top leading cause of cancer deaths among Chinese women. Human papillomavirus infection is the essential factor in the development of nearly all cases of cervical cancer. The virus-like particle (VLP) derived from LI gene coded by HPV genome induces the neutralization, as a result, the administration of VLP is effective against the infection of an HPV genotype. Since two HPV genotypes,i.e. ,HPV16 and 18 are most prevalent in the cervical …查看全部>>
张春杰
102206北京,中国疾病预防控制中心病毒病预防控制所病毒相关肿瘤室
乳头状瘤病毒疫苗宫颈肿瘤人乳头瘤病毒
Papillomavirus vaccines Uterine cervical neoplasms Human papillomavirus
《国际妇产科学杂志》 2011 (6)
513-516,4
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