国际妇产科学杂志2011，Vol.38Issue(6)：581-584,4.
来曲唑对人子宫肌瘤组织中MMP-2和TIMP-2表达的影响
Effect of Letrozole on the Expression of MMP-2 and TIMP-2 in Human Uterine Fibroids
龚霞红 1申清香 2刘珏 2周寿红3
作者信息
- 1. 413522 湖南省益阳市安化县第二人民医院妇产科
- 2. 南华大学附属第二医院妇产科
- 3. 南华大学医学院生理学教研室
- 折叠
摘要
Abstract
Objective:To investigate the effect of letrozole on matrix metalloproteinases-2(MMP-2) and tissue inhibitor of metalloproteinase-2(TIMP-2) in the patients with uterine fibroids. Methods: Forty patients with uterine fibroids were divided into two groups. Treatment group patients were received myomectomy after treatment with letrozole tablets (2.5 mg/day) for three course of treatment. Control group were only received myomectomy. The volume of uterus and uterine fibroids were measured through B-mode ultrasonography. The expression of MMP-2 and TIMP-2 in uterine smooth muscle and uterine fibroids were detected by Real-time PCR and Western Blot. Results:Compared with control group and in the treatment group, the clinical symptom was significantly improved, the level of estradiol was significantly decreased, the volume of uterus and uterine fibroids were markedly diminished,the expression of MMP-2 in uterine smooth muscle and u-terine fibroids was significantly decreased, the expression of TIMP-2 in uterine smooth muscle and uterine fibroids was markedly increased in the letrozole group. Conclusions:Letrozole diminishs the size of uterine fibroids in human,the mechanism which of may be related to the decrease of estradiol and MMP-2 expression and the increase of TIMP-2 expression induced by letrozole.关键词
来曲唑/子宫肌层/平滑肌瘤/基质金属蛋白酶2/金属蛋白酶2组织抑制剂Key words
Letrozole/ Myometrium/ Leiomyoma/ Matrix metalloproteinase 2/ Tissue inhibitor of metalloproteinase-2引用本文复制引用
龚霞红,申清香,刘珏,周寿红..来曲唑对人子宫肌瘤组织中MMP-2和TIMP-2表达的影响[J].国际妇产科学杂志,2011,38(6):581-584,4.
