国际妇产科学杂志2012，Vol.39Issue(1)：88-91,106,5.
子痫前期患者血清脂联素表达水平与血脂代谢及胰岛素抵抗的相关性
The Levels of Adiponectin,Lipids and Insulin Resistance and Their Relationship in Women with Pre-eclampsia
颜建英 1张东妹2
作者信息
- 1. 350001 福州,福建医科大学福建省妇幼保健院教学医院妇产科
- 2. 福建医科大学附属第二医院妇产科
- 折叠
摘要
Abstract
Objective:The purpose of the study was to detect the serum levels of adiponectin,insulin resistance and lipid metabolism in pre-eclampsia(PE),and to discuss their roles in the pathogenesis of PE. Methods:The level of adiponectin in serum was detected by enzyme-linked immunosorbent assay, and lipid and lipoprotein were dejected with biochemistry analyzer in a control group of thirty nonpregnant women, in sixty normal third-trimester pregnant women, and in sixty cases of women with PE. Results: ①Women with early-onset had a lower serum adiponectin level than its control, group Women with late-onset had a lower serum adiponectin level than its control (P＜0.05). Women with early-onset PE had a lower serum adiponectin level than late-onset PE group (P＜0.05). The differenceswere still significant after correction for haematocrit. ②In early-onset and late-onset PE group,the levels of total cholesterol(TC) ,triglyeride(TG) ,low density lipoprotein cholesterol (LDL) ,apolipoproteinB(ApoB) insulin and insulin resistance index (IRI) were higher thari that of their controls .while high density lipoprotein cholesterol (HDL) and apolipoproteinAl (ApoAl) were lower than that of their controls (P＜0.05). ③In early-onset and late-onset PE groups, the serum adiponectin was negatively related to the serum TG, systolic pressure (SP) ,diastolic pressure (DP), mean arterial blood pressure (MAP) and IRI, while the serum apdionectin was positively related to the serum HDL. Conclusions:Decreased adiponectin expression in serum may be involved in the pathogenesis of PE. Dyslipidemia and insulin resistance may be associated with decreased adiponectin expression in patients with PE, and may be involved in the pathophysiology of hypoadiponectinemia led to development of PE.关键词
先兆子痫/脂联素/胰岛素抗药性/脂类/血压Key words
Pre-eclampsia/ Adiponectin/ Insulin resistance/ Iipids/ Blood pressure引用本文复制引用
颜建英,张东妹..子痫前期患者血清脂联素表达水平与血脂代谢及胰岛素抵抗的相关性[J].国际妇产科学杂志,2012,39(1):88-91,106,5.
