国际口腔医学杂志2012，Vol.39Issue(1)：101-104,4.DOI:10.3969/j.issn.1673-5749.2012.01.028
抑制核因子-κB受体活化因子及其配体通路治疗牙周炎的研究进展
Research advances on inhibition receptor activator of nuclear factor-κB and its ligand in periodontal treatment
摘要
Abstract
Receptor activator of nuclear factor-KB(RANK) /receptor activator of nuclear factor-KB ligand(RAN-KL)blay a critical role in alveolar bone resorption though affecting osteoclasts formation and activation, therefore, we can inhibit periodontal bone resorption though RANKL/RANK inhibition. Osteoprotegerin(OPG) protects bone from excessive resorption by binding to RANKL and preventing it from binding to RANK. In this paper, we will review the relationship between RANKL/RANK/OPG signaling pathway and periodontal disease, and we will mainly focus on the possibility of periodontal treatment with RANKL/RANK inhibition.关键词
核因子-κB受体活化因子/核因子-κB受体活化因子配体通路/牙周治疗/牙槽骨吸收Key words
receptor activator of nuclear factor-κB/receptor activator of nuclear factor-KB ligand pathway/periodontal treatment/periodontal bone resorption分类
生物科学引用本文复制引用
陈斌..抑制核因子-κB受体活化因子及其配体通路治疗牙周炎的研究进展[J].国际口腔医学杂志,2012,39(1):101-104,4.基金项目
南京市卫生局青年科技人才启动基金资助项目(QYK-10166) （QYK-10166）
南京市留学回国人员科技活动基金资助项目(人社厅发[2008]86) （人社厅发[2008]86）
