国际医学放射学杂志2012，Vol.35Issue(2)：103-106,4.DOI:10.3784/j.issn.1674-1897.2012.02.L0201
多次X线暴露所致PC12细胞的氧化性损伤
Oxidative damage in PC12 cells induced by multiple X-ray exposures
喻晶 1刘宏 2葛宁 3张继青 2刁波 2陈福慈 4罗远菊 2吕玲1
作者信息
- 1. 430070,广州军区武汉总医院药剂科湖北中医药大学药学院
- 2. 广州军区武汉总医院肿瘤放疗科
- 3. 430070,广州军区武汉总医院药剂科
- 4. 广州军区武汉总医院医学实验科
- 折叠
摘要
Abstract
Objective To explore the oxidative damage in PC 12 cells induced by intermittent X-ray explosures. Method PC12 cells were irradiated with 50、150、450、1350 mGy of X-rays,respectively. The viability of PC12 cells, activity of superoxide dismutase(SOD), and level of Malondialdehyde (MDA) were evaluated after irradiation. Result Compared with the control group, the viability of PC 12 cells were above 100% at 50、150、450 mGy of X-ray explosure, while under 100% at 1 350 mGy. With the increase frequency of the irradiation, the viability were decreased, showing well correlation between the viability and the accumulation of irradiation. Followed the increase frequency of the irradiation, the activity of SOD was decreased; while the levels of MDA were increased at the irradiation dose of 150, 450 mGy, respectively. Conclusion Multiple middle-low dose irradiations could induce oxidative damage in PC 12 cells , and the level of damage is associated with the dose of irradiation.关键词
X线/PC12/细胞/氧化性损伤Key words
X-rays/ PC 12 cells/ Oxidative damage引用本文复制引用
喻晶,刘宏,葛宁,张继青,刁波,陈福慈,罗远菊,吕玲..多次X线暴露所致PC12细胞的氧化性损伤[J].国际医学放射学杂志,2012,35(2):103-106,4.
