国际病理科学与临床杂志2011，Vol.31Issue(6)：518-521,4.DOI:10.3969/j.issn.1673-2588.2011.12.014
孕妇血中胎儿微小RNA等核酸在唐氏综合征无创产前诊断中的应用
Fetal microRNA and other nucleic acids in maternal plasma for non-invasive prenatal diagnosis of Down syndrome
摘要
Abstract
Down syndrome is the most common chromosomal aneuploidy disease, and the birth defect intervention is an effective way to prevent it. Traditional prenatal diagnosis has some drawbacks such as invasivity, so more and more studies focus on the non-invasive prenatal diagnosis. The analysis of these 4 fetal markers ( fetal cells, cell-free fetal DNA, fetal messenger RNA, and fetal microRNA) in the circulation of pregnant women non-invasive prenatal diagnosis is one of the hottest current topics in prenatal medicine. Cell-free fetal microRNAs offer great hope for the non-invasive prenatal diagnosis because of its sufficient stability, high specificity, and accuracy.关键词
唐氏综合征/无创产前诊断/胎儿游离DNA/胎儿游离RNA/胎儿游离microRNAKey words
Down syndrome/ non-invasive prenatal diagnosis/ cell-free fetal DNA/ cell-free fetal RNA/cell-free fetal microRNA引用本文复制引用
欧阳琳娜,方婷,蒋锦梅,陆金梅,牛培,曾莉,谭三勤,张坚松..孕妇血中胎儿微小RNA等核酸在唐氏综合征无创产前诊断中的应用[J].国际病理科学与临床杂志,2011,31(6):518-521,4.基金项目
湖南省科技计划项目(2009JT3011) （2009JT3011）
国家级大学生创新性实验项目(101054265). （101054265）
