广西医科大学学报2011，Vol.28Issue(6)：821-823,3.
STZ复制实验性2型糖尿病大鼠模型过程及经验总结
PREPARATION AND EXPERIENCE OF RAT MODEL OF TYPE 2 DIABETES INDUCED BY STREPTOZOTOCIN
摘要
Abstract
Objective:To set up a SD rat model similar to human type 2 diabetes mellitus with insulin resistance. Methods:Thirty SD rats were randomized into three groups, A: normal group ( n =6), B: low-dose streptozotocin (STZ,30 mg/kg) group ( n =12),C: high-fat high-sugar diet and low-dose streptozotocin (STZ,30 mg/kg)group( n =12). Groups B and C were induced by an injection of low-dose STZC30 mg/kg) after 4 weeks of normal chow feeding and high-fat high-sugar chow feeding respectively. Results:The diabetes morbidity was 75% (8/12) in group B,100% (12/12) in group C. All rat model had symptoms of poly-dipsia and polyuria, bad fur and mental state, and emaciation. Conclusion:Both normal chow feeding associated with low-dose STZ (30 mg/kg) and high-fat high-sugar chow feeding associated with low-dose STZ (30 mg/kg) can establish type 2 diabetes animal model, but high-fat high-sugar chow feeding associated with low-dose STZ (30 mg/kg) had a high morbidity.关键词
2型糖尿病/STZ/大鼠/高脂高糖膳食Key words
type 2 diabetes/STZ/rats/high-fat high-sugar chow分类
医药卫生引用本文复制引用
申彦菊,彭岚,廖芝玲,陈青云..STZ复制实验性2型糖尿病大鼠模型过程及经验总结[J].广西医科大学学报,2011,28(6):821-823,3.基金项目
国家自然科学基金资助项目(No.303361) （No.303361）
