广西医学2012，Vol.34Issue(2)：138-140,3.
相思藤总黄酮对小鼠急性化学性肝损伤的保护作用及机制
Protective Effect and Mechanism of XIANGSITENG Flavonoid against Acute Chemical Liver Injuries in Mice
摘要
Abstract
Objective To investigate the protective effect and mechanism of XIANGSITENG flavonoid ( XSTF ) on CC14, AP and D-Galactosamine( D-GalN )-induced acute chemical liver injuries in mice. Methods The models of CC14 ,AP and D-GalN acute chemical liver injury in mice were used to study the effects of XSTF on acute chemical liver injury. The activities of ALT, AST in serum and the content of SOD, MDA, GSH and GSH-PX in hepatic tissue were measured. Results XSTF could significantly decrease the elevation of AST or ALT in liver injuries induced by CC14, AP or D-GalN in mice, which showed a does-effect relationship obviously. XSTF could obviously promote the content of SOD,GSH and GSH-PX in liver tissue,and decrease the MDA content significantly( P <0. 05 ). Conclusion XSTF could protect mice from CC14 ,AP and D-GalN-induced acute chemical liver injuries and its mechanisms may be related to attenuating free radical and inhibiting the lipid peroxidation.关键词
相思藤/总黄酮/化学性肝损伤Key words
XIANGSICHA/Flavonoid/Chemical liver injury分类
医药卫生引用本文复制引用
陈红霞,吴咖,黄仁彬,冯艺萍,焦杨..相思藤总黄酮对小鼠急性化学性肝损伤的保护作用及机制[J].广西医学,2012,34(2):138-140,3.基金项目
广西自然科学基金(2010GXNSFAO13170) （2010GXNSFAO13170）
