广西医学2012，Vol.34Issue(2)：144-147,4.
鼻咽癌组织中VEGF-C、LYVE-1表达与患者生存率的关系
Relationship between Expression of VEGF-C and LYVE-1 in Nasopharyngeal Carcinoma and Patients' Survival
摘要
Abstract
Objective To explore the relationship between expression of vascular endothelial growth factor-C ( VEGF-C ), lymphatic vessel endothelial hyaluronic acid receptor 1 ( LYVE-1 ) in nasopharyngeal carcinoma and patients' survival. Methods Immunohistochemistry( IHC ) was used to examine the expression of VEGF-C in 56 cases of nasopharyngeal carcinoma and 15 cases of normal mucous membrane of nasopharynx, and lymphatic vessel density ( LVD ) in nasopharyngeal carcinoma was counted by LYVE-1 staining which was specific marker for lymphatic vessel endothelial cell,and the relationships among VEGF-C,LVD and patents' survival were analyzed. Results ( 1 )The expression of VEGF-C in 56 cases of nasopharyngeal carcinoma and 15 cases of normal mucous membrane of nasopharynx were 83. 92%( 47/56 ) and 26. 7%( 4/15 ) respectively,and there was significant difference between these two groups ( P < 0. 01 ). LVD of nasopharyngeal carcinoma group was 20. 00 ±4. 37, LVD of normal mucous membrane of nasopharynx group was 10.12 ± 1. 79, and there was significant difference between these two groups( P < 0. 01 ). ( 2 )The relationship between VEGF-C, LVD and patients' survival: the 3-year cumulative survival of 56 cases of nasopharyngeal carcinoma was 64. 0% ,the Log-rank test showed that the 3-year cumulative survival of the patients with high expression of VEGF-C and high LVD was lower than that of the patients negatively with low expression of VEGF-C and low LVD( P < 0. 05 ). VEGF-C and LVD were correlated with the patients' survival( P < 0. 05 ). Conclusion Theexpression of VEGF-C and LVD in nasopharyngeal carcinoma is higher than that in normal mucous membrane of nasopharynx. Patients with high expression of VEGF-C and high LVD have low survival and poor prognosis.关键词
鼻咽癌/血管内皮生长因子-C/淋巴管密度/生存率Key words
Nasopharyngeal carcinoma/ Vascular endothelial growth factor-C/ Lymphatic vessel density/ Survival分类
医药卫生引用本文复制引用
姚平,林国彪,张锡流..鼻咽癌组织中VEGF-C、LYVE-1表达与患者生存率的关系[J].广西医学,2012,34(2):144-147,4.基金项目
广西科学基金(桂科基0832172) （桂科基0832172）
广西医疗卫生科研课题(桂卫Z2008185、桂卫Z2009340) （桂卫Z2008185、桂卫Z2009340）
广西中医学院重点课题(ZD2007015) （ZD2007015）
