广西医学2012，Vol.34Issue(3)：275-278,4.
荧光原位杂交技术在急性早幼粒细胞白血病诊断及治疗中的应用价值
Value of Fluorescence in Situ Hybridization in the Diagnosis and Treatment of Acute Promyelocytic Leukemia
摘要
Abstract
Objective To investigate the application of fluorescence in situ hybridization( FISH ) for the detection of PML-RARa fusion gene in the diagnosis and treatment of acute promyelocytic leukemia( AFL ). Methods PML-RARa fusion gene detection was performed in 21 patients suspected of APL by FISH. Results Of the 21 suspected APL patients, fifteen cases were confirmed of APL. Positive PML-RARa fusion genes were found in 14 of the IS APL patients,while one case with negative PML-RARa fusion gene was confirmed to be variant APL and was treated with all-trans retinoic acid ( ATRA )-induction therapy but the efficacy was poor. The remaining 6 suspected APL patients with negative PML-RARa fusion gene were confirmed to be acute myeloid leukemia-M2. Conclusion Detection of PML-RARa fusion gene by FISH is sensitive and reliable, and is of great value for the diagnosis and treatment of APL.关键词
急性早幼粒细胞白血病/荧光原位杂交/PML-RARa融合基因Key words
Acute promyelocytic leukemia/ Fluorescence in situ hybridization/ PML-RARa fusion gene分类
医药卫生引用本文复制引用
周瑞莲,莫耀禧,蓝梅,林金盈..荧光原位杂交技术在急性早幼粒细胞白血病诊断及治疗中的应用价值[J].广西医学,2012,34(3):275-278,4.基金项目
广西医药卫生科研课题(桂卫Z2008057 （）
桂卫Z2009133) （）
