河北工业科技2011，Vol.28Issue(6)：359-363,368,6.
尤特奇RS-PO/RL-PO制备缓释片的工艺研究
Technical study on sustained release tablets preparation of Eudragit RS-PO/RL-PO
韩巧玲 1张丽 1徐凌云 1姚清娇 1张多成1
作者信息
- 1. 石药集团中诺药业(石家庄)有限公司,河北石家庄050051
- 折叠
摘要
Abstract
For better application of Eudragit RS-PO and RL-PO, the sustained release properties are compared. Using theo-phylline as a model drug and Eudragit RS-PO and RL-PO as sustained release materials for preparation of theophyline sustained release tablets and coated sustained released tablets. Eudragit RS-PO and RL-PO release properties are tested through in vitro release test. RS-PO has a relatively strong retard property, which is not recommended to be used alone as a skeleton sustained-release material. RL-PO is considered as an ideal release material with relatively strong release property and strong controlling effect on release. Formability of film coating and toughness of RS-PO is not ideal, and the drug penetration is extremely poor, therefore, it is not recommended to be used as a coating material. RL-PO can be chosen as a sustained release material for osmotic pump preparation, for it has better coating film formation property and relative better plasticity toughness. The film membranes remain intact through the release process and it has good drug penetration property.关键词
尤特奇 RS-PO和RL-PO/荼碱/骨架缓释片/包衣缓释片Key words
Eudragit RS-PO and RL-PO/theophylline/skeleton frame-sustained release tablets/coating sustained release tablets分类
医药卫生引用本文复制引用
韩巧玲,张丽,徐凌云,姚清娇,张多成..尤特奇RS-PO/RL-PO制备缓释片的工艺研究[J].河北工业科技,2011,28(6):359-363,368,6.
