河北医学2012，Vol.18Issue(3)：297-300,4.DOI:10.3969/j.issn.1006-6233.2012.03.005
血清肿瘤标记物对非小细胞肺癌的诊断价值
Diagnostic Value of Single and Combined Determination of Serum TPS Cyfra21-1 and Ferritin in patients with NSCLC
刘广军 1谢宗涛1
作者信息
- 1. 苏州大学附属第四医院,江苏,无锡,214062
- 折叠
摘要
Abstract
Objective: To investigate the diagnostic value of single and combined determination of serum tissue polypeptide specific antigen( TPS ), cytokeratin 19 fragment(Cyfra21-1 ) and ferritin in patients with non-small cell lung cancer( NSCLC ). Method: The levels of serum TPS were detected in 108 patients with NSCLC and 86 cases of healthy adults by enzyme-linked immunosorbent assay( ELASA ),and the levels of Cyfra21-1 and ferritin were detected by electrochemiluminescence. Result: The serum levels and positive rates of the three tumor markers in lung cancer group were significantly higher than those in healthy adults( P <0. 01 ). TPS showed higher sensitivity than the other two tumor markers in the diagnosis of pulmonary ade-nocarcinoma( P<0. 05 );The serum levels and positive rates of Cyfra21-1 in squamous carcinoma group were significantly higher than those in adenocarcinoma group( P<0. 01 ). TPS showed the highest sensitivity and Cyfra21-1 showed the highest sensitivity in single tumor marker detection; Their combined detection could reduce the specificity to a certain extent,but could significantly improve the sensitivity and the accuracy( P< 0. 01 ). Conclusion: The single and combined detection TPS,cyfra21-l and ferritin has high clinical value in the diagnosis of NSCLC and the differentiation of pathology types.关键词
非小细胞肺癌/肿瘤标记物/组织多肽特异性抗原/细胞角蛋白19片段Key words
Non-small cell lung cancer/ Tumor marker/ Tissue polypeptide specific antigen/ Cytokeratin 19 fragment引用本文复制引用
刘广军,谢宗涛..血清肿瘤标记物对非小细胞肺癌的诊断价值[J].河北医学,2012,18(3):297-300,4.
