河北医学2012，Vol.18Issue(3)：302-305,4.DOI:10.3969/j.issn.1006-6233.2012.03.007
慢性单纯性苔藓患者单个核细胞凋亡与细胞因子 IGF-1的关系
Relationship between the Apoptosis of Mononuclear Cell and the Expression of Cytokines and Insulin-like Growth Factor-1 in Patients with Lichen Simplex Chronicus
易恒安1
作者信息
- 1. 广东省深圳市龙岗区横岗人民医院,广东,深圳,518115
- 折叠
摘要
Abstract
Objective: To observe the changes of mononuclear cell ( MNCs ) apoptosis and the level of inflammatorycy tokines and IGF-1 in patients with lichen simplex chronicus, and to study the relationship between them. Method: The apoptosis of MNCs in 38 patients with lichen simplex chronicus and 10 healthy controls were determined with flow cytometry. The inflammatory cytokines and the IGF -1 were tested with ELISA method. Result: The percentage of MNCs apoptosis in the patients with lichen simplex chronicus was significantly higher than that of healthy controls. The levels of IL-8, TNF-a, IL-6, IGF-1 in patients with lichen simplex chronicus were significantly higher than those of healthy controls, and the increased levels o f inflammatory cytokines and IGF-1 in lichen simplex chronicus patients were positively correlated to the percentage of MNCs apoptosis. Conclusion: The data demonstrates that there is a promote apoptotic process of MNCs inactive lichen simplex chronicus. The high expression of inflammatory cytokines and IGF-1 may play an important role in promoting MNCs apoptosis which reduces the functional life span of MNCs. For this reason, modulating the expression of cytokines, IGF-1 and moderately controlling the apoptosis of MNCs may be a new therapeutic target for lichen simplex chronicus treatment .关键词
慢性单纯性苔藓/细胞凋亡/细胞因子/单个核细胞Key words
Lichen simplex chronicus/ Apoptosis/ Cytokines/ Mononuclear cell引用本文复制引用
易恒安..慢性单纯性苔藓患者单个核细胞凋亡与细胞因子 IGF-1的关系[J].河北医学,2012,18(3):302-305,4.
