郑州大学学报（医学版）2012，Vol.47Issue(1)：57-60,4.DOI:10.3969/j.issn.1671-6825.2012.01.018
急性白血病患者骨髓单个核细胞中BAG-1及Bcl-2蛋白的表达
Expressions of BAG-1 and Bcl-2 proteins in bone marrow mononuclear cells from patients with acute leukemia
李江 1万鼎铭2
作者信息
- 1. 郑州大学第一附属医院血液科,郑州,450052
- 2. 河南职工医学院内科教研室,郑州,451191
- 折叠
摘要
Abstract
To explore the BAG-1 and Bcl-2 expressions in bone marrow mononuclear cells from patients with a-cute leukemia( AL ). Methods:The expressions of BAG-1 and Bcl-2 in bone marrow mononuclear cells were detected by SP immunocytochemical staining assay in untreated AL group( 112 cases ),AL complete remission( AL-CR ) group( 57 cases ), relapsing and refractory AL( RRAL ) group ( 29 cases ), and normal control group( 20 cases ). Results:There were significant differences in the positive expression rates of BAG-1 and Bcl-2 proteins among the 4 groups (X2 =61. 795,37. 866, P < 0. 001 ), and the positive rates of the two proteins in untreated AL group and RRAL group were significantly higher than those in AL-CR group and normal control group ( P<0.001 ). In untreated group,there was a marked relation between the expression of BAG-1 and the number of WBC in peripheral blood or leukemic infiltration(X2 = 16. 336, 19. 289, P < 0.001 ),and BAG-1 positive rate was associated with Bcl-2( rp =0. 587,P <0. 001 ). Conclusion:BAG-1 combined with Bcl-2 may play an important role in the pathogenesis and progression of AL.关键词
BAG-1/Bcl-2/急性白血病Key words
Bcl-2 associated athanogene/Bcl-2/acute leukemia分类
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李江,万鼎铭..急性白血病患者骨髓单个核细胞中BAG-1及Bcl-2蛋白的表达[J].郑州大学学报（医学版）,2012,47(1):57-60,4.
