郑州大学学报（医学版）2012，Vol.47Issue(1)：85-88,4.DOI:10.3969/j.issn.1671-6825.2012.01.027
野菊花水提液对豚鼠离体回肠收缩的影响及抑菌作用观察
Effects of Flos chrysanthemum indicum on the bacterial pathogens and the muscular tension of the isolated ileum of guinea pigs
白银亮 1田新慧 1毕跃峰 1王盼 1张旗1
作者信息
摘要
Abstract
To investigate the antibacterial effects of water extract of Flos chrysanthemum indicum and its effects on muscular tension of the isolated ileum of guinea pigs. Methods: The isolated guinea pig ileum in the organ-bath was used to measure the contractive tension of smooth muscle before and after administration of drug. Double dilution method was used to observe the antibacterial effect of water extract of Flos chrysanthemum indicum. Results: Water extract of Flos chrysanthemum indicum inhibited dose-dependently the contraction of normal guinea pig ileum( F = 11. 088, P <0. 001 ) and that induced by acetyl choline and diphenhydramine( F = 13. 881 and 19. 305 ,P < 0. 001 ). It also had antibacterial effects on Escherichia coli ,Pseudomonas aeruginosa, Bacillus subtilis, and especially on Staphylococcus aureus with a lowest antibacterial dosage of 125 g/L. Conclusion: Water extract of Flos chrysanthemum indicum relaxes the smooth muscle of ileum of guinea pigs, and can effectively inhibit the growth of bacteria in vitro.关键词
野菊花/豚鼠/离体回肠/乙酰胆碱/组胺/抑菌作用Key words
Flos chrysanthemum indicum/guinea pig/isolated ileum/acetyl choline/diphenhydramine/antibacteria分类
医药卫生引用本文复制引用
白银亮,田新慧,毕跃峰,王盼,张旗..野菊花水提液对豚鼠离体回肠收缩的影响及抑菌作用观察[J].郑州大学学报（医学版）,2012,47(1):85-88,4.
