郑州大学学报（医学版）2012，Vol.47Issue(2)：170-174,5.DOI:10.3969/j.issn.1671-6825.2012.02.010
肠道病毒71型河南分离株2株全基因组序列分析
Analysis of complete genome sequence of two enterovirus 71 strains isolated from Henan
摘要
Abstract
Aim:To analyze the genome of two enterovirus 71 isolated strains obtained from Luoyang and Nanyang in Henan province in 2011. Methods: Two enterovirus 71 isolated strains from Luoyang and Nanyang, respectively, was obtained and the complete genome sequence and phylogenetic analysis were analyzed. Results: The nucleotide sequence of VP-1 regions in EV71/Luoyang2011 and EV71/Nanyang2011 should be classified phylogenetically as subtype C4, which were mostly close to Guangdong Strain in 2008, and shared higher sequence homology with other domestic EV71 strains of China. They were similar to each other, and nucleotide and amino acid sequence identities were 99. 3% and 97. 6% , respectively. The amino acid sequence identities of them had hardly variation. Conclusion: EV71/Luoyang2011 and EV71/ Nanyang2011 belong to subtype C4,and have little variation with other former EV71 strains in China.关键词
肠道病毒71型/手足口病/同源性分析/河南Key words
enterovirus71/hand-foot-and-mouth disease/homology analysis/Henan province分类
医药卫生引用本文复制引用
冷弘,卢欣,刘慧涛,马云云,王媛媛,马晶,郭茂峰,李敏,赵国强..肠道病毒71型河南分离株2株全基因组序列分析[J].郑州大学学报（医学版）,2012,47(2):170-174,5.基金项目
河南省医学科技攻关基金资助项目 200902006 （）
