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发酵法转化乙二醇制备乙醇酸

魏胜华 孟娜 郑长龙 李婉珍

化工进展2012,Vol.31Issue(2):397-401,5.
化工进展2012,Vol.31Issue(2):397-401,5.

发酵法转化乙二醇制备乙醇酸

Preparation of glycolic acid by the fermentation of ethylene glycol

魏胜华 1孟娜 1郑长龙 2李婉珍1

作者信息

  • 1. 安徽工程大学生物与化学工程学院,安徽芜湖241000
  • 2. 北京利德曼生化股份有限公司,北京100176
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摘要

Abstract

In this paper the fermentation process of glycolic acid from ethylene glycol by Gluconobacter oxydans is studied.The results showed that the optimal fermentation condition was as follows:the ethylene glycol concentration was 80 g/L,adding 40 g/L of sorbitol to the medium as supplement carbon source in order to promote cell growth,1.0mol/L of sodium hydroxide and ammonia mixture was the neutralizer used in the fermentation process to maintain pH of 5.5.After 40hrs fermentation,the production of glycolic acid was 97.4 g/L,the yield was 96.8%.The method established the foundation for the biological production of glycolic acid.

关键词

乙醇酸/乙二醇/氧化葡萄糖酸杆菌/发酵

Key words

glycolic acid/ethylene glycol/Gluconobacter oxydans/fermentation

分类

生物科学

引用本文复制引用

魏胜华,孟娜,郑长龙,李婉珍..发酵法转化乙二醇制备乙醇酸[J].化工进展,2012,31(2):397-401,5.

基金项目

安徽工程大学人才引进基金项目 ()

化工进展

OA北大核心CSCDCSTPCD

1000-6613

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