化工学报2011，Vol.62Issue(12)：3428-3433,6.DOI:10.3969/j.issn.0438-1157.2011.12.018
金刚烷直接氧化制备金刚烷多元醇新工艺
A novel synthesis of adamantane polyhydric alcohols by direct oxidation of adamantane
摘要
Abstract
Adamantane polyhydric alcohols are important active intermediates for synthesis of adamantane-based specific medicines, fine chemicals and functional materials. In this paper, three adamantane polyhydric alcohols, including adamantane-1, 3-diol, adamantane-1, 3, 5-triol and adamantane-1, 3, 5, 7-tetraol were synthesized via one-step oxidation reaction of adamantane by using Cr ( VI ) reagents as oxidants, acetic acid as solvent under the mild conditions. The structures of adamantane-1, 3-diol, adamantane-1, 3, 5-triol and adamantane-1, 3, 5, 7-tetraol were confirmed by IR, 1H NMR and element analysis. Influences of synthesis conditions on the oxidation reaction were investigated. The reaction mechanism of adamantane oxidation by Cr ( Ⅵ ) reagents was discussed as well. Under the optimum conditions, adamantane-1, 3-diol, adamantane-1, 3, 5-triol and adamantane-1, 3,5, 7-tetraol could be synthesized with the yields of 71%, 42% and 35% respectively. Such synthesis technology for adamantane polyhydric alcohols is of potential for application because of brief reaction, convenient manipulation, and the mild conditions and so on.关键词
金刚烷/氧化/金刚烷多元醇Key words
adamantane/ oxidation/ adamantane polyhydric alcohols分类
化学化工引用本文复制引用
付长安,郭建维,刘卅,崔英德,杨楚芬,彭进平,崔亦华..金刚烷直接氧化制备金刚烷多元醇新工艺[J].化工学报,2011,62(12):3428-3433,6.基金项目
番禺科技计划项目(2009-z-40-1) （2009-z-40-1）
广东工业大学重大培育专项(405095220). （405095220）
