黑龙江八一农垦大学学报2011，Vol.23Issue(4)：30-32,3.
甲氧苄啶对连翘体外抗菌增效作用的研究
Study on Antibacteria Synergitic Effect of Trimethoprim Combined with Forsythia Suspensa in Vitro
摘要
Abstract
The minimum inhibitory concentrations（MIC） of forsythia suspensa,trimethoprim（TMP） and forsythia suspense combined with TMP were measured individually by the method of microdilution checkerboard techniques against Staphylococcus aureus,Escherichia Coli and Salmonella.The fractional inhibitory concentrations（FIC） indices were calculated on forsythia suspensa combined with TMP.The number of Staphylococcus aureus,Escherichia Coli and Salmonella were enumerated by plate counts methods,which had been inhabited by forsythia suspensa combined with TMP for 1,2,4 and 8 h.The bactericidal rate of forsythia suspensa combined with TMP was calculated.The experimental data were fitted by least squares method,and the optimal dose of compatibility was determined on TMP combined with forsythia suspensa.The results showed that the FIC values on Staphylococcus aureus and Escherichia Coli were 0.5,0.5 respectively.The effect of drugs combination showed synergistic action.The FIC value on Salmonella was equal to 0.75.The effect of drugs combination was taken on additive action.The optimal dose of compatibility were 7.2 mg·g-1 on TMP combined with forsythia suspensa in vitro.关键词
连翘/甲氧苄啶/抗菌作用/增效作用Key words
forsythia suspensa/trimethoprim/antibacterial action/synergistic action分类
农业科技引用本文复制引用
王新,崔一喆,邵红..甲氧苄啶对连翘体外抗菌增效作用的研究[J].黑龙江八一农垦大学学报,2011,23(4):30-32,3.基金项目
黑龙江省农垦总局科技攻关项目 （）
