湖南中医药大学学报2012，Vol.32Issue(1)：20-22,3.DOI:10.3969/j.issn.1674-070X.2012.01.005.020.03
丹紫康膝冲剂对兔膝骨性关节炎软骨含水率及羟脯氨酸影响的研究
Effects of Danzi Kangxi granule on cartilage water and hydroxyproline of knee osteoarthritis in rabbits
摘要
Abstract
Obj ective To investigate the effects of Danzi Kangxi granule(DKG)on the content of water and hydroxyproline in cartilage of rabbits with knee osteoarthritis. Methods Rabbits were randomly divided into 6 groups, I.e. DKG high dose group(HDG), medium dose group(MDG), low dose group(LDG), modeling control group(MCG)and Bone -Strengthening Joint Pills group(BSJPG). Except the control group, all the rabbits were treated with 0.5 mL 4% papain injected into the left knee joints in the 1st, 4th and 7th days in one week. Then, the cartilage water and hydroxyproline were determined. Results Obvious degenerative pathological changes were found in the in MCG. Compared with MCG, the content of cartilage water and hydroxyproline were markedly lower in HDG, MDG and LDG statistically(P<0.05); the cartilage water content in in HDG and MDG were lower than that in LDG(P<0.05); the differences of hydroxyproline betweenHDG and MDG was not signifecant(P<0.05), but data of there two groups have significant differences comparing with LDG(P<0.05). Conclusion Danzi Kangxi granule can improve the levels of cartilage water and hydroxyproline in knee osteoarthritis, in which the high and medium dosage are much bettrer in rabbits.关键词
丹紫康膝冲剂/膝骨性关节炎/软骨/羟脯氨酸/兔/紫河车/丹参Key words
Danzi Kangxi granule/knee osteoarthritis/cartilage/hydroxyproline/rabbits/dried human placenta/salvia分类
医药卫生引用本文复制引用
陈孟交,王桂蒙,肖四旺,陆小龙,尤冬春..丹紫康膝冲剂对兔膝骨性关节炎软骨含水率及羟脯氨酸影响的研究[J].湖南中医药大学学报,2012,32(1):20-22,3.基金项目
湖南省自然科学基金资助项目(09JJ6055). （09JJ6055）
