摘要
Abstract
The DNA-binding behavior of eight 6-aliphatic amine substituted naphthalimide derivatives was investigated by UV-vis absorption spectra, fluorescence spectra, circular dichroism (CD) and viscosity measurement The significant fluorescence quenching of 3a, 3b, 3c and 3d having stronger DNA-binding efficiency was observed upon addition of DNA, while the significant fluorescence enhancement of 3e, 3f, 3g and 3h having weaker DNA-binding efficiency was seen. CD results indicated that the change the secondary DNA structure induced by the derivatives was different In UV-vis and viscosity measument, no obvious difference in the interaction of the derivatives and DNA was found. Taking the spectra and viscosity measurement results, it was concluded that the naphthalimide derivatives bound to DNA via intercalation and there was differential in the degree of the interactioa.关键词
萘酰亚胺/小牛胸腺DNA/光谱/粘度/相互作用/嵌插方式Key words
naphthalimide/ calf thymus DNA/ spectra/ viscosity/ interaction/ intercalated binding分类
医药卫生
