湖南农业大学学报（自然科学版）2012，Vol.38Issue(1)：117-120,4.DOI:10.3724/SP.J.1238.00117
铜(Ⅱ)烟酸与L-α-丙氨酸三元配合物的固相合成和表征及抑菌活性
Solid phase synthesis, characterization and antibacterial activity of copper (Ⅱ) with nicotinic acid and L-α-alanine
摘要
Abstract
A copper (Ⅱ) complex with nicotinic acid and L-α-alanine was synthesized by the method of room temperature solid phase synthesis. The complex was characterized through elemental analysis, infrared spectra, ultraviolet spectra and X-ray powder diffraction. The results showed that the COO- group of nicotinic acid and the amino nitrogen and carboxylic oxygen of L-a-alanine coordinated with Cu2+. Antibacterial test displayed that the complex have a certain antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Bacillus aeruginosus, Aeromonas hydrophila and Yersinia intermedia, and the activity against Bacillus subtilis was the strongest with the inhibition diameter of 13.4 mm at the concentration of 0.5 mmol/L. The minimal inhibitory concentration of the complex against bacillus subtilis was 0.031 25 mmol/L.关键词
烟酸/L-α-丙氨酸/铜配合物/固相合成/抑菌活性Key words
nicotinic acid/ L-α-alanine/ copper complex/ solid phase synthesis/ antibacterial activity分类
化学化工引用本文复制引用
谢勇平,李清禄,郑新宇,蔡碧琼..铜(Ⅱ)烟酸与L-α-丙氨酸三元配合物的固相合成和表征及抑菌活性[J].湖南农业大学学报（自然科学版）,2012,38(1):117-120,4.基金项目
福建省跨越计划办公室项目(闽农科教[2010]352号) （闽农科教[2010]352号）
