化学工程2012，Vol.40Issue(1)：5-8,34,5.
烷基三唑硫酮席夫碱的合成和生物活性研究
Synthesis and biological activities of 5-alkyl-4-amino-1,2,4-triazole-3-thione Schiff bases
摘要
Abstract
In order to further study the synthesis and properties of Schiff bases of triazole, five triazolethione Schiff bases were synthesized by using 5-alkyl-4-amino-l, 2, 4-triazole-3-thione with p-methoxyacetophenone and substituted aldehydes as raw materials in the presence of glacial acetic acid as catalyst under refluxing reaction of 0. 5 h. The structures of the compounds were characterized by elemental analysis, infrared spectroscopy (IR) , and nuclear magnetic resonance ( 1H NMR). The results show that all the compounds have the CH = N characteristic absorption band at 1 587-1 603 cm-1 in IR, and the proton chemical shift of CH =N is around δ = 10.5 and the H shift of N =C-CH3 is around δ = 2. 4 in 1H NMR. Their biological activities to the five vegetable pathogens of Gibberella nicotiancola, Pythium solani, Gibberella saubinetii, Alternaria iycopersici and Fusarium oxysporium f. S. P. Niveum were tested. The toxic regression equation and correlation coefficient were obtained. The EC50 and EC95 were calculated. The results show that they exhibit good fungicidal activities. The Schiff bases containing an electron withdrawing substituent have better fungicidal activities than those containing an electron donating substituent.关键词
三唑硫酮/席夫碱/合成/生物活性Key words
triazolethione/ Schiff base/ synthesis/ biological activity分类
化学化工引用本文复制引用
陆文婷,孙晓红,刘源发,陈邦,靳如意..烷基三唑硫酮席夫碱的合成和生物活性研究[J].化学工程,2012,40(1):5-8,34,5.基金项目
国家自然科学基金资助项目(21073141) （21073141）
西北大学研究生创新基金资助项目(10YZZ32) （10YZZ32）
