华西口腔医学杂志2011，Vol.29Issue(6)：604-609,6.DOI:10.3969/j.issn.1000-1182.2011.06.011
S-100蛋白、CD1a、CD83及Ki-67在口腔朗格汉斯细胞组织细胞增生症中的表达及意义
The expression of S-100 protein, CD1a, CD83 and Ki-67 in oral Langerhans cell histiocytosis
赵业 1郑亚鸽 2张丽慧 3姚甜 3吴兰雁3
作者信息
- 1. 大同市第三人民医院 口腔科,大同037008
- 2. 四川省双流县妇幼保健院 口腔科,成都610200
- 3. 四川大学华西口腔医院病理科,成都610041
- 折叠
摘要
Abstract
Objective To study clinicopathological features, diagnosis, differential diagnosis of oral Langerhans cell histiocytosis (LCH), retrospective clinicopathologic study was carried on and a variety of immune phenotype were de tected. Methods The clinicopathological features of 29 cases of oral LCH were analyzed. The immunohistochemical staining of S-100 protein, Cdla, CD83 and Ki-67 were used in above cases by immunohistochemical streptavidin-biotin peroxidase (SP) and Elivison two-step method. Statistical analysis was adopted for the results. Results Of the 29 cases of LCH, the expression of S-100 protein and Cdla were positive in 24 cases and negative in 5 cases, so 5 cases were excluded from the diagnosis of LCH. Among 24 cases of LCH, 15 patients were male and 9 were female. The median age was 730 years. 14 lesions were in the mandible, 5 were in the maxilla and 5 involved the mandible and maxilla. 9 cases were in stage Ⅰ , 13 in stage Ⅱ and 2 in stage Ⅲ, according to Bartniek classification. Immuno-histochemistry showed all 24 cases staining for S-100 protein and Cdla were positive. Comparing with maxillofacial lesions involved soft tissue, Ki-67 positive rate was lower and CD83 positive rate was higher in maxillofacial single bone lesion. Conclusion The immunohistochemical staining of S-100 protein and Cdla are important for the diagnosis of LCH. Maxillofacial bone single LCH might have lower proliferative activity and a higher state of maturity. Maxillofacial LCH involved soft tissue might have a higher proliferative activity and a lower state of maturity.关键词
朗格汉斯细胞组织细胞增生症/S-100蛋白/CD1a/CD83/Ki-67Key words
Langerhans cell histiocytosis/S-100 protein/Cdla/CD83/Ki-67分类
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赵业,郑亚鸽,张丽慧,姚甜,吴兰雁..S-100蛋白、CD1a、CD83及Ki-67在口腔朗格汉斯细胞组织细胞增生症中的表达及意义[J].华西口腔医学杂志,2011,29(6):604-609,6.
