四川大学学报（医学版）2012，Vol.43Issue(1)：91-94,4.
高危局限进展性肾透明细胞癌术后辅助应用干扰素-α的生存分析
Survival Analvsis of Interferon-all ha on Locally Advanced Clear Cell Renal Cell Carcinoma after Radical Nephrectomy
夏娟 1李响 2陈雪芹 1李雄 2曾浩 2魏强 2张朋 2朱育春2
作者信息
- 1. 四川大学华西医院病理研究室,成都 610041
- 2. 四川大学华西医院泌尿外科,成都 610041
- 折叠
摘要
Abstract
Objective To evaluate the effect of interferon-alpha (IFN-a) on locally advanced clear cell renal cell carcinoma (ccRCC) after radical nephrectomy in terms of tumor progression free survival (PFS) and overall survival (OS). Methods 176 cases with locally advanced ccRCC were followed up in West China Hospital from 1999 to 2007. All patients were divided into two groups according to whether treated with IFN-a as adjuvant therapy. PFS and OS were analyzed with Kaplan-Meier method and Cox regression model. Results Median follow-up was 48 months, 53 cases of disease progressed, and 37 were dead. Mortality rate within treatment and observed groups were 44. 3% and 18. 6%, respectively (P<0. 001). There were significant differences between the two groups in PFS C(59. 12±5. 04) months vs. (81. 42±5. 84) months,P = 0. 005] and OS CC74. 66±4. 77) months vs. (85. 18±4. 92) months,P=0. 031] Cox regression model demonstrated that IFN-a, as adjuvant therapy after surgery, was an independent negative risk factor for the prognosis of locally advanced clear cell renal cell carcinoma. Conclusion IFN-a was ineffective in locally advanced ccRCC after radical nephrectomy in terms of PFS and OS, and there is no evidence that IFN-a could be considered as adjuvant therapeutic drug.关键词
肾透明细胞癌/辅助治疗/干扰素-α/疗效Key words
Clear/cell/renal/cell/carcinoma/Adjuvant/therapy/Interferon-a/Treatment/effect引用本文复制引用
夏娟,李响,陈雪芹,李雄,曾浩,魏强,张朋,朱育春..高危局限进展性肾透明细胞癌术后辅助应用干扰素-α的生存分析[J].四川大学学报（医学版）,2012,43(1):91-94,4.
