海洋科学2011，Vol.35Issue(12)：75-81,7.
水产养殖环境常见四环素类抗生素抗性基因tet（M）的演化及传播的初步分析
Study of evolution and dissemination of common tetracycline resistance tet（M） genes in aquaculture
摘要
Abstract
Antibiotic resistance genes as new pollutant have been received increasingly wide attention, and their mechanisms of access and routes of transmission have become the focus of research. tet（M） gene is a common tetracycline resistance gene in many environmental media. In this study, the genetic characteristic, polymorphism and phylogenic relationship of 20 tet（M） gene sequences in aquaculture with their bacterial hosts and environmental media sources were analyzed using molecular phylogenetic method. There are 4 haplotypes in these 20 tet（M） gene sequences, in which tet（M）-b and d are two distinct types of tetracline resistance determinants, while the other two types are sequence variation of tet（M）-b and d; Three clear clades were found in the phylogeny tree, and the evolution and transmission of tet（M） gene had nothing to do with the taxonomy of their bacteria hosts and environmental sources, suggesting the spreading mechanism and environmental toxicity of tet（M） gene need to be further studied.关键词
抗生素抗性基因/四环素/tet（M）/水产养殖/多样性Key words
antibiotic resistance gene tetracycline tet（M） gene aquaculture diversity分类
农业科技引用本文复制引用
陈琳琳,刘维青,刘静,张高生,任宗明..水产养殖环境常见四环素类抗生素抗性基因tet（M）的演化及传播的初步分析[J].海洋科学,2011,35(12):75-81,7.基金项目
烟台市科学技术发展计划项目 （）
