基础医学与临床2012，Vol.32Issue(2)：128-132,5.
骨髓和脂肪来源的间充质干细胞免疫调节作用的比较
Comparison of immuno-modulatory properties between bone-marrow derived MSCs and adipose derived MSCs
摘要
Abstract
Objective To compare MSCs' immuno-modulatory property between bone-marrow derived and adipose derived MSCs. Methods Phenotype analysis of both MSCs populations was detected by flow-cytometry. To analyse immuno-modulatory effect of MSCs, proliferation, cell cycle, activation, apoptosis and Thl/Th2 balance were analyzed after co-culturing lymphocytes and MSCs. Results Phenotype analysis showed that AMSCs had the similar expression of markers with BMSCs. Both AMSCs and BMSCs could inhibit T cells proliferation and activation. AlsoMSCs' effect on Th cell differentiation into Thl or Th2 was similar between AMSCs and BMSCs. Nevertheless, BMSCs could suppress activated T cell apoptosis, while AMSCs could not. Conclusions AMSCs and BMSCs showed similar immuno-modulatroy effect on T lymphocytes, however the difference effect on activated T cell apoptosis of the two cell populations is still unclear and the mechanism needs to explore.关键词
骨髓间充质干细胞/脂肪间充质干细胞/免疫调节Key words
bone marrow derived MSCs/adipose derived MSCs/immuno-modulatory分类
医药卫生引用本文复制引用
孙昭,韩钦,赵春华..骨髓和脂肪来源的间充质干细胞免疫调节作用的比较[J].基础医学与临床,2012,32(2):128-132,5.基金项目
国家自然科学基金青年基金(30800429) （30800429）
"长江学者和创新团队发展计划"项目(IRT0909) （IRT0909）
