基础医学与临床2012，Vol.32Issue(3)：273-277,5.
不同脂肪含量的高脂纯化配方饲料对大、小鼠代谢综合征发生的影响
Effect of diets with different fat content on metabolic syndrome of rats and mice
摘要
Abstract
Objective To examine potential effect of diets with different fat content on body weight, blood glucose and insulin levels, serum total cholesterol (Tch) and triglycerides (TG) concentrations, fatty liver and daily urinary albumin excretion in rats and mice. Methods Males Sprague Dawley (SD) rats and C57BL/6 mice were ran-domly divided into three groups and fed on diets with 10% fat content (MD10% fat) , 45% fat content (MD45% fat) , and 60% fat content (MD60% fat) for 12 weeks, respectively. Body and organ weight, blood glucose and insulin levels, and serum Tch and TG concentrations, liver Tch and TG contents and daily urinary albumin excretion were measured. Results Compared with the controls ( MD10% fat) , the animals fed with high-fat diets ( MD45%f at and MD60% fat) showed a significant increase in body weight, blood glucose and insulin levels, glucose intolerance, serum Tch and TG concentrations, hepatic Tch and TG contents and albuminuria levels. Furthermore, body weight gain and insulin resistance were more profound in animals fed with the MD45% fat diet. Conclusions Both high-fat diets (MD45% fat and MD60% fat) can produce most phenotypes of metabolic syndromein SD rats and C57BL/6 mice, with the former being more effective.关键词
高脂饲料/胰岛素抵抗/肥胖/代谢综合征Key words
high-fat diet/insulin resistance/obesity/metabolic syndrome分类
医药卫生引用本文复制引用
周云枫,李沙,苏文,黄世铮,蒲丹,管又飞..不同脂肪含量的高脂纯化配方饲料对大、小鼠代谢综合征发生的影响[J].基础医学与临床,2012,32(3):273-277,5.基金项目
科技部973项目(2012CB517504) （2012CB517504）
国家自然科学基金(81100611) （81100611）
高等学校博士学科点专项科研基金(20110001120020) （20110001120020）
