基础医学与临床2012，Vol.32Issue(3)：345-348,4.
核酸适配体在肿瘤学中的应用研究进展
Progress in aptamers for cancer research
胡燕 1杨先达1
作者信息
- 1. 中国医学科学院基础医学研究所北京协和医学院病理生理研究室,北京100005
- 折叠
摘要
Abstract
Aptamers, generated by the SELEX ( systematic evolution of ligands by exponential enrichment) technology, are single stranded DNA or RNA molecules that can specifically bind to their targets with high affinity. Aptamers from Cell-SELEX are widely applied as targeting molecules in different fields, including the detection of cancer cells, targeted drug delivery systems and siRNA researches. Both in vivo and in vitro studies demonstrated that aptamers could be successfully used for in vitro cancer cells detecting, in vivo cancer imaging and enhancing the cytotoxicity of drugs or siRNAs towards cancer cells.关键词
核酸适配体/Cell-SELEX/肿瘤细胞检测/靶向药物载体/siRNAKey words
aptamer/cell-SELEX/cancer cells detection/targeted drug carrier/siRNA分类
医药卫生引用本文复制引用
胡燕,杨先达..核酸适配体在肿瘤学中的应用研究进展[J].基础医学与临床,2012,32(3):345-348,4.
