解放军医学杂志2012，Vol.37Issue(2)：156-159,4.
血红素加氧酶-1与肾脏损伤
Kidney injury and heme oxygenase-1
摘要
Abstract
Heme oxygenase-1 (HO-l) is one of the main pathways to degrade heme in mammals, and the main degradation products are free iron (Fe2+), carbon monoxide (CO), and bilirubin. Heme plays an important role in promoting cell survival, circulation of intracellular substrates, and immune regulation. Previous studies suggest that the heme-HO-1 pathway is an important internal factor in determining the susceptibility and severity of acute kidney injury (AKI). The induction of HO-l expression can attenuate the severity of renal ischemia-reperfusion injury (IRI), and the inhibition of HO-l expression will accentuate the injury of IRI. The present article summarizes the latest advances in research into HO-l regarding the protective mechanism on AKI conducted abroad and at home to learn more information about HO-l in the treatment of AKI.关键词
血红素加氧酶-1/肾疾病/再灌注损伤Key words
heme oxygenase-1/ kidney diseases/ reperfusion injury分类
医药卫生引用本文复制引用
麦海星,陈立军,陈彪,游华,张旭..血红素加氧酶-1与肾脏损伤[J].解放军医学杂志,2012,37(2):156-159,4.基金项目
国家自然科学基金(81001220) （81001220）
