解剖学杂志2011，Vol.34Issue(6)：758-762,5.
喉癌中血管内皮素-1的表达与血管内皮生长因子-C、淋巴管生成及预后的关系
Relationship between endothelin-1 expression and vascular endothelial growth factor -C, lymphangiogenesis as well as prognosis in human laryngeal cancer
摘要
Abstract
Objective-. To investigate the expression of endothelin-1 (ET-1) in patients with laryngeal cancer, and the relationship with vascular endothelial growth factor-C (VEGF-C), lymphangiogenesis, lymph node metastasis and their prognosis significance. Methods-. Forty five specimens of the laryngeal cancer and twenty benign laryngeal diseases were studied. The expression of ET-1 and VEGF-C was observed by immunohistochemistry staining S-P method. Lymphatic vessel density (LVD) was evaluated by 5 -nucleotides-alkaline phosphates double staining, and then the role of ET-1, VEGF-C, ET-1+/ VEGF-C+ in laryngeal cancer prognosis was judged by using Kaplan-Meier method. Results-. The expression of ET-1, VEGF-C were much higher in tumor tissue than in the normal tissue,and the expression of ET-1 was significantly correlated with VEGF-C. The expression of ET-1 was significantly correlated with peritumoral LVD, intratumoral LVD, TNM stage, lymphatic metastasis and lymphovascular invasion. There was no significant correlation in their age, gender, histological stage and location. The different expression of ET-1 had no effect on survival ratio, while the different expression of ET-1+/VEGF-C+ and VEGF-C had effect on survival ratio. As well, ET-1+/VEGF-C+ had a significant high risk death rate. Conclusion-. The expression of ET-1 protein was correlated with lymphangiogenesis and lymphatic metastasis, ET-1 and VEGF-C axis may play cooperation roles in lymphangiogenesis and lymphatic metastasis. Combined detection of ET-1 protein and VEGF-C protein may be helpful for judging prognosis in laryngeal cancer.关键词
血管内皮素-1/血管内皮生长因子-C/喉癌/淋巴管生成/预后Key words
endothelin-1/vascular endothelial growth factor C/laryngeal cancer/lymphangiogenesis/prognosis引用本文复制引用
王莹,李文媛,杨春壮,贾桦,佟晓杰..喉癌中血管内皮素-1的表达与血管内皮生长因子-C、淋巴管生成及预后的关系[J].解剖学杂志,2011,34(6):758-762,5.基金项目
黑龙江省普通高等学校青年学术骨干支持计划项目(1152G050) （1152G050）
黑龙江省卫生厅科研项目(2010243) （2010243）
