解剖学杂志2011，Vol.34Issue(6)：766-769,4.
高血脂对大鼠脑缺血再灌注损伤后海马内胶质纤维酸性蛋白表达的影响
Effect of hyperlipemia on GFAP expression in the hippocampus after cerebral ischemic-reperfusion injury in rats
摘要
Abstract
Objective-. To observe the effect of hyperlipemia on glial fibrillary acidic protein (GFAP) expression in the hippocampus CA4 in rats after ischemia-reperfusion in the braia Methods-. Application of high-fat diet produced lipid model. The focal cerebral ischemic-reperfusion model was established with thread embolism of the middle cerebral artery. Immunohisto-chemistry, Western blot and neurobehavioral evaluation were used to examine the expression of GFAP in the hippocampus CA4 in the side of cerebral ischemia-reperfusion and neurological function disorders. Results-. Compared with sham-operation group, the number of astrocyte and the expression of GFAP were increased in both cerebral ischemia-reperfusion groups in the same time point. Compared with cerebral ischemia-reperfusion group, the expression of GFAP was decreased, the population of positive astrocyte declined, cell body was small and process was slender in hyperlipemia with cerebral ischemia-reperfusion group. Conclusion-. After cerebral ischemia-reperfusion, the number and shape of astrocyte and the expression of GFAP present dynamic changes.关键词
胶质纤维酸性蛋白/星形胶质细胞/高血脂/脑缺血再灌注Key words
glial fibrillary acidic protein/astrocyte/high blood lipids/cerebral ischemia-reperfusion引用本文复制引用
任占川,李瑞梅,杨迎春..高血脂对大鼠脑缺血再灌注损伤后海马内胶质纤维酸性蛋白表达的影响[J].解剖学杂志,2011,34(6):766-769,4.基金项目
山西省高校科技研究开发项目(200613049) （200613049）
