计算机应用与软件2012，Vol.29Issue(1)：159-163,5.
miRNA研究的计算机方法
COMPUTATIONAL APPROACH FOR miRNA RESEARCH
摘要
Abstract
Abstract MicroRNAs (miRNAs) are one class of the newly identified non-coding RNAs with endogenous length at approximate 21-23-nucleotides which can regulate gene expression. miRNAs regulate gene expression at posttranscriptional level by directly cleaving targeted mRNAs or repressing translation. A series of researches show that they play important roles in cell differentiation, proliferation, growth, mobility, and apoptosis. As an alternative, computational approaches have been developed due to time consuming, high cost and low efficiency in experimental approaches. Most computational approaches associated with miRNA research can be categorised into three classes: miRNAs gene identification, miRNAs target gene prediction and miRNA-mRNA regulatory modules prediction. In this review, we summarise the principles of miRNAs gene identification, predictions of miRNAs target gene and miRNA-mRNA regulatory module, and provide a survey on specific computational methods that have been proposed in the field.关键词
MicroRNA/计算机方法/基因表达/miRNA-mRNA调控模块Key words
MicroRNA/Computational approach/Gene expression/miRNA-mRNA regulatory modules分类
信息技术与安全科学引用本文复制引用
张俊鹏,孙少平,贺建峰,马磊..miRNA研究的计算机方法[J].计算机应用与软件,2012,29(1):159-163,5.基金项目
云南基础应用研究基金(2009ZC049M) （2009ZC049M）
昆明理工大学科学研究基金会(2009-022). （2009-022）
