实用临床医药杂志2011，Vol.15Issue(21)：1-4,4.
18-α甘草酸对大鼠四氯化碳慢性肝损伤的治疗作用
Treatment of 18 - α glycyrrhizic acid for chronic liver injury induced by carbon tetrachloride in rats
徐中南 1徐铭益 2陆伦根 1吴锡铭 1王佩 3张喜全 3夏春光 2戴峻 2朱玲 2李琨 2曲颖2
作者信息
- 1. 上海交通大学附属第一人民医院消化科,上海,200080
- 2. 江苏正大天晴药业股份有限公司,江苏南京,210018
- 3. 浙江省杭州市第六人民医院,浙江杭州,310014
- 折叠
摘要
Abstract
Objective To observe the treatment of 18 - α glycyrrhizic acid (18 - α - GA) for chronic liver injury induced by CC1 4 in rats. Methods The rats were subcutaneously injected with 25% CCl4 in olive oilof 2 mL/kg for 13 weeks, twice one week. The treatment group in the fifth week was consecutively intraperitoneally injected 18 α - GA 15, 30, 60 mg/kg respectively, once a day to week 13. In 24 hours of the end time to18 - α - GA, the rats were put to death, blood serum or plasma were separated and the ALT, AST, total protein, albumin, globulin, saliva acid, nitric oxide and hyaluronic acid were detected. The content of hydroxyproline in liver tissue was determined and the pathological changes of liver tissues were examined. Results 18 - α - GA could improve liver function of chronic liver injury induced by CC14 in rats, decrease NO level, and reduce the activity of liver tissue inflammation and the progression of fibrosis. Conclusion 18 - α - GA might have cura-tive effect on chronic liver injury induced by CC14 in rats.关键词
18-α甘草酸/四氯化碳/肝损伤,慢性/大鼠Key words
18 -a glycyrrhizic acid/ CCl4/ liver injury, chronic/ rats分类
医药卫生引用本文复制引用
徐中南,徐铭益,陆伦根,吴锡铭,王佩,张喜全,夏春光,戴峻,朱玲,李琨,曲颖..18-α甘草酸对大鼠四氯化碳慢性肝损伤的治疗作用[J].实用临床医药杂志,2011,15(21):1-4,4.
