摘要
Abstract
Objective To evaluate the clinical value of radioiodine - 131 SPECT/CT image in patients with differentiated thyroid carcinoma. Methods Two hundred and eight cases of both whole body scans and SPECT/CT images were studied, which performed in 5 ~ 7 days after receiv-ing 3.7~11.1 GBq of radioiodine- 131 by oral intake for radioablation of thyroid remnants or recur-rent and metastatic foci after a thyroidectomy in one hundred forty - two patients with differentiated thyroid carcinoma. Results The truth - positive, false - positive, false - negative and truth - nega-tive of 131I - SPECT/CT images for detecting DTC recurrent and metastatic foci were 427, 2, 14 and 208 respectively, but those of 131I- WBS were 245, 14, 48 and 155. The sensitivity and accu-racy of 131I - SPECT/CT images in this study for detecting DTC recurrent and metastatic foci were 96.8% and 97.5%, which were significantly higher than 131I - WBS(P<0. 001, P<0.001), whereas those of 131I - WBS were 83.6 % and 86.5 % respectively. The specificity of 131I - SPECT/ CT images for detecting recurrent and metastatic foci in DTC patients was higher than 131I - WBS (0. 01<F<0.05), which were 99.1% and 91.7% respectively. Conclusion A post - therapeutic 131 I - SPECT/CT image can accurately locate recurrent or metastatic foci of DTC and eliminate the false - positive lesion such as radiopollution, tissues covering and so on. The sensitivity, accuracy and specificity of 131I - SPECT/CT images for detecting recurrent and metastatic foci in DTC pa-tients were higher than 131I - WBS. It is helpful in determining clinical stage, therapeutic effects, prognosis and therapeutic strategies of DTC patients. The method of post - therapeutic 131 I -SPECT/CT image is demonstrated higher clinical value in the DTC patients.关键词
分化型甲状腺癌/放射性131碘/单光子发射计算机断层/X射线透射计算机断层Key words
differentiated thyroid carcinoma/ radioiodine-131/ single photon emission computed tomography/X - Ray transmission computed tomography (SPECT/CT)分类
医药卫生
