实用临床医药杂志2011，Vol.15Issue(24)：27-30,4.
桂皮酸联合Ndfip1对人肝癌细胞SMMC-7721细胞增殖与凋亡的协同效应
Synergistic effects of cinnamic acid combined with Ndfip1 on proliferation and apoptosis of liver cancer cell 7 721
摘要
Abstract
Objective To detect the proliferation and apoptosis of liver cancer cell 7 721 by different concentrations and different time of cinnamic acid or by cinnamic acid combined with Ndfipl. Methods The proliferation of liver cancer cell 7 721 induced by different times and different concen trations of cinnamic acid alone or combined with Ndfipl were detected through MTT assay. The apopto sis of liver cancer cell 7 721 induced by different times and different concentrations of cinnamic acid a lone or combined with Ndfipl were detected through flow cytometry. Results Different concentration of cinnamic acid alone or combined with Ndfipl inhibited the cell proliferation of SMMC -7 721 and increased cell apoptosis of SMMC -7 721 as well. The combined action had better effect. Significant difference was shown in the data of the two groups. Conclusion Combined with Ndfipl, the inhibited rate of proliferation and apoptosis rate of SMMC - 7 721 cells increased significantly compared with cinnamic acid alone, illustrating that the role of cinnamic acid combined with Ndfipl may have syner gistic effects.关键词
肝癌7721细胞/桂皮酸/Ndfip1Key words
liver cancer cell 7721/ Ndfipl/ cinnamic acid分类
医药卫生引用本文复制引用
吕俊明,左安华,王永振,张瀛丹,程宏..桂皮酸联合Ndfip1对人肝癌细胞SMMC-7721细胞增殖与凋亡的协同效应[J].实用临床医药杂志,2011,15(24):27-30,4.基金项目
国家自然科学基金(31071216/C0706)和江苏省自然科学基金(BK2010306)资助 （31071216/C0706）
