实用临床医药杂志2012，Vol.16Issue(1)：33-35,3.
糖耐量受损和2型糖尿病患者脂联素水平的相关性研究
Evaluation of adiponectin level in association with impaired glucose tolerance and type 2 diabetes
孙斌 1黄珊1
作者信息
- 1. 上海市长宁区中心医院,上海,200336
- 折叠
摘要
Abstract
Objective To explore the relationship between plasma level of lipoprotein and insulin resistance in type 2 diabetes (T2D) patients with impaired glucose tolerance (IGT). Methods Patients with IGT (n= 41) and T2D (n = 96) were recruited for this study. - Subjects with normal glucose tolerance (n =29) served as controls. Plasma level of lipoprotein, glucose, insulin and adiponectin was measured. Insulin resistance index was calculated by using HOMA- IR. The differences between groups (IGT, T2D and controls) were analyzed by using Logistic regression. Results In controls, IGT and T2D, the plasma adiponectin levels were found to be significantly different at 15.8 ± 3.6 mg/L (mean ± SD), 10.7 ± 2.4 mg/L and 6.3 ± 2.4 mg/L respectively (P <0.05). BMI, plasma total cholesterol level and insulin resistance index of IGT patients were significantly higher than those of the controls (P < 0. 05). Logistic regression analysis showed that BMI, plasma level of high density lipoprotein, total cholesterol and fasting insulin, together with insulin resistance index were risk factors for the deterioration to IGT in controls. Fasting plasma insulin level was the only risk factor in our study in prediction of IGT to T2D. Plasma level of adiponectin was a protective factor in both glycemia deteriorations. Conclusion Plasma adiponectin level decreases with the increase of insulin resistance index in IGT patients who are on an early stage of T2D. Hypoadiponectinaemia can be used as a biomarker for diagnosis and prediction in T2D.关键词
2型糖尿病/糖耐量受损/胰岛素抵抗/脂联素Key words
type 2 diabetes/ impaired glucose tolerance/ insulin resistance/ adiponectin分类
医药卫生引用本文复制引用
孙斌,黄珊..糖耐量受损和2型糖尿病患者脂联素水平的相关性研究[J].实用临床医药杂志,2012,16(1):33-35,3.
