实用临床医药杂志2012，Vol.16Issue(1)：74-76,3.
螺内酯对老年慢性心力衰竭患者心功能和血浆脑钠肽的影响
Effect of spironolactone on the cardiac function and plasma brain natriuretic peptide (BNP) in elderly patients with chronic heart failure
摘要
Abstract
Objective To investigate the role of spironolactone in the treatment of chronic heart failure. Methods Sixty- two patients with chronic heart failure were divided into conventional group (n = 30) and spironolactone group ( n = 32). The conventional group received ACEI, digitalis, thiazide diuretics, β-blockers and other conventional treatments. Spironolactone group took oral spironolactone treatment in addition to the conventional treatment. Serum BNP levels, LVEF and VE/VA before and after 4 months of the treatment were observed. The treatment efficacy after 1 month of the treatment was observed as well. Results One month after treatment, the total efficiency (90.6% ) of spironolactone group was significantly higher than that of the conventional group (70%). LVEF and VE/VA of spironolactone group were significantly higher than those of the conventional group (P<0.05). After treatment, the serum BNP levels of both groups decreased. The spironolactone group had more significant decreases (P < 0. 05). Conclusion Spironolactone can significantly improve cardiac function and decrease serum BNP levels in elderly patients with chronic heart failure.关键词
螺内酯/慢性心力衰竭/心功能/脑钠肽Key words
spironolactone/ chronic heart failure/ heart function/ brain natriuretic pep-tide分类
医药卫生引用本文复制引用
上官佳红,张红苗,苏杨..螺内酯对老年慢性心力衰竭患者心功能和血浆脑钠肽的影响[J].实用临床医药杂志,2012,16(1):74-76,3.基金项目
中国高校医学期刊临床专项资金(11120034) （11120034）
