扬州大学学报（农业与生命科学版）2011，Vol.32Issue(4)：11-14,4.
Ki-67、Bcl-2和Bax蛋白在不同睾酮水平鼠前列腺中的表达及相关性
Correlation and expression of Ki-67, Bcl-2 and Bax in prostate tissues of different testosterone level rats
摘要
Abstract
32 SD rats were randomly assigned to normal group(N) , castrated group(C) , vasectomy group(V) and testosterone group (T), Different testosterone level models of rats were established by castrating, vasoligating or subcutane-ously injecting testosterone, respectively. The sex hormones in serum and prostate tissues were determined separately and the expression of Ki-67, Bcl-2 and Bax in prostate tissues with RIA and IHC methods the correlation between them were sdudied. Results showed that there were a decrease of serum T and prostate T in different degree in C group and V group and an obvious increase in T group (P<0. 01). There were.high positive correlation between T levels of serum and prostate and expression of Ki-67and Bcl-2/Bax ratio in epithelial cells of prostate (P<0. 01) and no significant correlation in stromal cells (P>0. 05). Testosterone may regulate proliferation and apoptosis of prostatic epithelial cells by affecting the expression of Ki-67, Bcl-2 and Bax.关键词
睾酮大鼠模型/前列腺组织/增殖与凋亡Key words
testosterone rat models/ prostate tissues/ proliferation and apoptosis分类
医药卫生引用本文复制引用
盛树东,于有江,王冬艳,钱小妹,肖望书..Ki-67、Bcl-2和Bax蛋白在不同睾酮水平鼠前列腺中的表达及相关性[J].扬州大学学报（农业与生命科学版）,2011,32(4):11-14,4.基金项目
江苏省卫生厅科研项目(J201009) （J201009）
